La Crosse, Wisconsin, is a beautiful place known for its parks, architecture, and historical sites. From outdoor adventures to cultural arts offerings, La Crosse has much to offer for anyone looking for a great place to live—or a fantastic weekend getaway.La Crosse County was settled by fur traders in the late 18th century and further populated and incorporated by lumber barons in the mid-19th century. Today, La Crosse County is home to world-class medical facilities. The two best examples are Gundersen Health System and Mayo Clinic Health System.